NEXUS, now called simply "the Machine" by it's human enemies, is the artificially intelligent computer system that used to run just about everything on the world or planet of Splicers until it suffered a serious of malfunctions. Eventually, these programming bugs grew until NEXUS gained a series of seven different personalities, most of which wanted to exterminate humanity largely or totally

Over a century later, survivinng humans are either part of the Resistance, which is grouped in vatious Houses dedicated to fighting "the Machine", who uses it's legions of robots and drones to combat them.

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