Thanks to the Machine (NEXUS computer) attempting to commit genocide against them, the humans of the Machine's planet have divided into Houses that live underground, with each led by a Warlord who is advised by their House's Senate. Each House also has a military armed with biotech weapons and an elite force called the Dreadguard. See the article on Splicers.

Each House also has converted humans called Librarians and Engineers who manufacture biotech.

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